日誌
結節硬化症或結節本身，應該是細胞內鈣太多造成細胞變成纖維化、鈣化的結節。 ... ...
After treatment with osteogenic induction medium, osteoblast proliferation, ALP activity, mineralized nodule formation, and intracellular calcium levels were markedly increased in osteoblasts from 1d group
用成骨誘導培養基處理後，1d組成骨細胞的成骨細胞增殖、ALP活性、礦化結節形成和細胞內鈣水平顯著增加
The number of nodules, defined by a collagenous core and a bounding cell layer detached from the alveolar wall, was determined by morphometry. Lungs showed increased alveolar wall collagen and fibrotic nodules at 79 and 116 days of exposure with increased collagenase and gelatinase activity.
由膠原核心和從肺泡壁分離的邊界細胞層定義的結節數量通過形態測量法確定。在暴露的第 79 天和第 116 天，肺部顯示肺泡壁膠原蛋白和纖維化結節增加，膠原酶和明膠酶活性增加。
Using regression analysis, cystic fibrosis patients were seen to exhibit significantly higher free intracellular calcium concentrations than the controls over the time span covered.
使用回歸分析，發現囊性纖維化患者在所涵蓋的時間跨度內表現出明顯高於對照組的游離細胞內鈣濃度。
Intracellular calcium increases significantly as human fibroblasts age in culture. The calcium increase occurs 5 to 6 weeks (passages) earlier and is significantly greater in fibroblasts from subjects with cystic fibrosis in comparison with cells from control subjects. Intracellular calcium, which is thought to be a pathogenetic factor in cystic fibrosis, may also be a meaningful marker in cell aging.
隨著人類成纖維細胞在培養中年齡的增長，細胞內鈣顯著增加。與來自對照受試者的細胞相比，來自囊性纖維化受試者的成纖維細胞中的鈣增加提前 5 至 6 週（傳代）發生並且顯著更大。 細胞內鈣被認為是囊性纖維化的致病因素，也可能是細胞衰老的一個有意義的標誌物。
結節性硬化症 Tuberous Sclerosis Complex (TSC)
The name tuberous sclerosis comes from the characteristic tuber or potato-like nodules in the brain, which calcify with age and become hard or sclerotic.
結節性硬化症的名稱來自大腦中特徵性的塊莖或馬鈴薯樣結節，隨著年齡的增長鈣化並變硬或硬化。
小結1：
結節硬化症或結節本身，應該是細胞內鈣太多造成細胞變成纖維化、鈣化的結節。
總結以上：
結石的結晶核產生可能和細胞內鈣過多有關
告訴我們：
不只提升IL-4及IL-2減少細胞內游離鈣(intracellular calcium)
IL-10、IFN-r也能經由胞吐減少細胞內游離鈣(intracellular calcium)
細胞內鈣的快速增加直接觸發調節的胞吐作用。
IL-10、IL-2、IFN-r都可產生去極化
去極化誘導的胞吐作用
能提高IL-4的元素：
鎂、鋅、鈣、維生素A、維生素C、兒茶素、花青素、茄紅素、薑黃素、黃酮類化合物(
生物類黃酮、大豆異黃酮)、鞣花酸
能提高IL-10的元素：
鎂、鈣、鋅、錳、硒、維生素A、維生素D、維生素E、兒茶素、花青素、薑黃素、鐵、碘、茄紅素、黃酮類化合物(生物類黃酮、大豆異黃酮)、鞣花酸
能提高IL-2的元素：
鋅、銅、硒、鈣、維生素A、維生素C、維生素E、大豆異黃酮、兒茶素、花青素、茄紅素、多醣體(燕麥多醣體)、牛磺酸
能提高IFN-γ的元素：
鋅、硒、錳、維生素A、維生素C、高劑量維生素E、兒茶素、茄紅素、大豆異黃酮、多醣體(燕麥多醣體)
